When less is more: how many doses of PCV are enough?

How many doctors are enough?

How Many Earths Are Enough?

The goals of NASA’s Terrestrial Planet Finder (TPF) and ESA’s Darwin missions are to find and characterize terrestrial planets in the habitable zones of other stars, and to search for evidence of life in the atmospheres of any planets found. A key issue that must be addressed is the size of the sample of stars that must be searched before the scientific community, the funding agencies, and the ...

When Less is More

engine and airframe manufacturers for decades have cited the direct relationship between engine wear and high exhaust gas temperature (EGT) in recommending that operators use less than maximum takeoff thrust whenever possible. While the cost benefits of reduced-thrust takeoffs are thoroughly documented, the safety benefits are not as well understood. Thus, there is a common perception that usin...

When Less is More.

minimum level. Sometimes more really is more, and less really is less. But often, less is more. If all this piece does is open up the question of whether less is more —if all it does is remind the reader that this is a question, and that our answers to it have important repercussions— then it will have served its purpose. Many ethicists in the ancient tradition argued that human lives could be ...

How many events is enough? Are you positive?

ONE of the more perplexing problems in flow cytometry revolves around the issue of: ‘‘Is it real’’? If a sample has one event in a particular gate, is that event real? Is it significant? Should it be believed? Is the sample ‘‘positive’’? If the answer to these is ‘‘No’’, then what is the threshold number of events above which the answer becomes ‘‘Yes’’? Flow cytometry is unique among biological...